Solving novel RNA structures using only secondary structural fragments
نویسندگان
چکیده
منابع مشابه
Solving novel RNA structures using only secondary structural fragments.
The crystallographic phase problem is the primary bottleneck encountered when attempting to solve macromolecular structures for which no close crystallographic structural homologues are known. Typically, isomorphous "heavy-atom" replacement and/or anomalous dispersion methods must be used in such cases to obtain experimentally-determined phases. Even three-dimensional NMR structures of the same...
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ژورنال
عنوان ژورنال: Methods
سال: 2010
ISSN: 1046-2023
DOI: 10.1016/j.ymeth.2010.06.011